SMALP network

SMALP Conference Registration

Our conferences bring together scientists from disciplines including biochemistry, biophysics, polymer chemistry, and chemical, molecular and cell biology in order to explore the latest conceptual and technical developments related to biomembranes.

The development of innovative methods for extracting and stabilizing membrane complexes such as SMA and related copolymers, scaffolds, saposins, peptidiscs, and native vesicles has driven progress in this growing field.

Models of membranes including fluid mosaic, lipid raft, mattress, membron, membrome, microdomain, nanodomain, and picket and fence hypotheses have been proposed, with the proteolipid code providing an inclusive and unifying framework, with a basis in memtein structural biology.

The advances rely on novel agents that fragment membranes into water-soluble nanodiscs, allowing the complex native structures and interactions found in vivo to be discerned without the scrambling and destabilization caused by conventional detergents.

New tools and models for discerning how membrane zones form and operate across cellular and evolutionary spaces provides insights into structures and functions of organelle and organ systems, as well as guiding biomarker and drug discovery.

Register: SMALP Webconference on June 18, 2024

Program on Tuesday June 18, 2024

7:00 am MST SMALP Industry Club & Membrane Protein Paris 2024 planning meeting

8:45 am Mountain Standard Time Tips and Tricks session to share practical advice

Session 1 chaired by Prof Bert Klumperman, University of Stellenbosch

adam evans9:00 Adam Evans, PhD student with Tim Dafforn at U Birmingham, on Optimising the Purification Process: Exploring Affinity Resins and Polymer Combinations using the RePol Screen.

Tharushi Wijesiriwardenaalex snow9:20 Alex Snow, Postdoctoral Researcher, and Tharushi Wijesiriwardena, Research Technician with Stephen Muench University of Leeds Astbury Biostructure Laboratory on Incorporating SMALPs into a novel cell-free system

9:40 break

Session 2 chaired by Dr Rakesh Bhat, University of Alberta

claire coupland9:45 Claire Coupland, Postdoctoral Researcher with John Rubinstein, The Hospital for Sick Children, on cryo-EM of V-ATPase in native synaptic vesicles

jz10:05 Kai (Jack) Zhang, Assistant Professor, Yale U: In-situ Structures of Mammalian Mitochondrial Respiratory Supercomplexes in Reaction within Native Mitochondria

10:25 break

Session 3 chaired by Prof Tim Dafforn, University of Birmingham

tk10:30 Troy Kervin, PhD Student with Peijun Zhang at U Oxford published how membranes are functionalized by the proteolipid code and will present "Open questions about membrane zonation"

Noemi Jiménez-Rojo 10:50 Noemi Jiménez-Rojo, Ikerbasque Research Fellow, Dept of Biochemistry, UPV/EHU, who published on cracking the membrane lipid code

Satyajit Mayor11:10 Satyajit Mayor, Professor, National Centre for Biological Sciences, Bangalore, India on membrane organization, models and nanoclusters

11:30 break

Session 4 chaired by Prof Barry Bruce, University of Tennessee, Knoxville

pt11:35 Peter Tieleman, Professor, University of Calgary and Canada Research Chair in Molecular Simulation, on membrane modeling and fingerprinting

gn11:55 Garth Nicolson, President, The Institute for Molecular Medicine on the updated Singer-Nicolson Fluid-Mosaic Model of Cell Membranes

12:15 Discussion and close

Pre-register: Membrane Protein Paris 2024 on Oct 14

Speakers include:

Amedee des GeorgesAmedee des Georges, Associate Professor, Molecular Pathobiology, NYU: deciphering the gating mechanism of RyR1 using temperature-resolved cryo-EM

Bjørn PedersenBjorn Pedersen, Professor, Dept. of Molecular Biology & Genetics, Aarhus University, Denmark, with a focus on transmembrane transporters

ChiaraChiara Rapisarda, Group Leader in cryo-EM at Sanofi, developing new capabilities to accelerate drug discovery

Claire de MarchClaire de March, Assistant Professor, CNRS, Institute of Chemistry of the Natural Substances, University Paris Saclay, studying olfactory receptors

Daniel CapellutoDaniel Capelluto, Associate Professor, Virginia Tech: Mechanisms of regulation of endosomal cargo transporters

isabelle-Mus-VeteauIsabelle Mus-Veteau, CNRS Research Director, Institut de Pharmacologie Moléculaire and Cellulaire: Drug efflux activity of the Hedgehog receptor Patched

Leonid SazanovLeonid Sazanov, Professor, Institute of Science and Technology Austria: Structures and coupling mechanism of respiratory complex I, a huge molecular machine

Manuela ZoonensManuela Zoonens, Senior Researcher, CNRS, Paris & Institut de Biologie Physico-Chimique, Université Paris Cité, with a focus on amphipols

Background on SMALP

The SMALP system is being developed by the international research community as an alternative to conventional detergents, which tend to dissociate, destabilize and deactivate native membrane proteins.

SMA polymer

A variety of amphipathic polymers like styrene maleic anhydride have been found to directly and spontaneously solubilize proteins and bound lipids from membranes when activated. This provides opportunities for understanding and exploiting the structure and function of native membrane protein complexes.

As SMALP technology is relatively new, the participation of the wider community and sharing of new ideas and practices amongst researchers is the best way to ensure continued rapid development of the field.

Join our network and come to our meetings to discover how SMALP materials and methods could be used in your research.

Join our community.

The SMALP network offers polymers, methods and meetings to support the growing community of scientists and companies interested in the preparation of membrane nanodiscs formed by polymers including styrene maleic acid for biological research and drug discovery applications.

Register for a day of insightful talks from experts in the structural biology and functions of membrane proteins and nanodisc development, discussions with academic and industry leaders, and enjoy breakfast, lunch and coffee breaks on us.

These events are offered to bring together academic and industry experts, postdocs and students who are interested in membrane protein structural biology, lipidomics, proteomics, target discovery and biophysical analysis of bilayers and amphipathic polymers.

We welcome researchers from across academia and industry to join us in lively discussions and debate about the latest advances in native nanodiscs, membrane proteins, polymer chemistry, lipid biophysics, structural biology, and applications including drug discovery and delivery.